Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Antioxidant, biofilm inhibition and mutagenic activities of newly substituted fibrates

Asma Sheikh¹ , Zia-Ur-Rehman ², Muhammad Imran¹, Zaid Mahmood¹

¹Institute of Chemistry, University of the Punjab, Lahore; ²Applied Chemistry Research Centre, PCSIR, Labs, Complex, Lahore, Pakistan.

For correspondence:- Asma Sheikh Email: asmasheikhso@yahoo.com

Accepted: 25 May 2019 Published: 30 June 2019

Citation: Sheikh A, Z, Imran M, Mahmood Z. Antioxidant, biofilm inhibition and mutagenic activities of newly substituted fibrates. Trop J Pharm Res 2019; 18(6):1227-1234 doi: 10.4314/tjpr.v18i6.12

© 2019 The authors.
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Abstract

Purpose: A series of benzylidene-2-(4-bromophenoxy)-2-methyl propane hydrazides (1-10) were synthesized and assay them for their biofilm inhibition, antioxidant and mutagenic. .

Methods: All derivatives were prepared by condensation of various substituted benzaldehyde and acetophenones with 2-(4-bromorophenoxy)-2-methyl propane hydrazide, which was itself prepared by hydrazinolysis of ethyl-2-(4-bromophenoxy)-2-methyl propanoate and were characterized by FTIR, ¹H NMR ¹³C NMR, mass spectrometry. They were screened for their in-vitro anti-oxidant, biofilm inhibition and mutagenicity by established methods.

Results: Anti-oxidant results revealed that the electron donating group enhanced the scavenging ability of the compounds as seen in compounds 4b, 4h and 4i. In biofilm inhibition studies, all compounds were more active against Gram –ive bacterial strain when compared to gram +ive strain. The mutagenicity assay results indicate that the compound having chloro group substitution is mutagenic.

Conclusion: The benzylidine compounds of 2-(4-bromophenoxy)-2-methyl hydrazide possessing electron donating substituents exhibit superior activities to the electron withdrawing group substituents.

Keywords: Fibrate derivatives, Anti-oxidant, Biofilm inhibition, Mutagenic activity